PHARMACOGENETICS APPROACH TO THERAPEUTICS

non-corrective approach to pronunciation

the aim of this study has been to find answers for the following questions: 1. what is the effect of immediate correction on students pronunciation errors? 2. what would be the effect of teaching the more rgular patterns of english pronunciation? 3. is there any significant difference between the two methods of dealing with pronuciation errore, i. e., correction and the teaching of the regular ...

Pharmacogenetics and Pharmacogenomics : Applications in Drug Development and Therapeutics

Pharmacogenetics and pharmacogenomics is an emerging science that has a great application in drug development and therapeutics. It improves individualized therapy and gives crucial approach individuals with variability in drug response due to heredity thereby promotes personalized medicine. Pharmacogenomics intends to develop rational means of optimizing drug therapy, with respect to the patien...

Challenges and Promises of Pharmacogenetics in Cancer Therapeutics

Genetic constitution represents an important cause for individual variations in the response and tolerance to drug treatment. Th ese variations are due to the germline mutations in genes that encode for drug-metabolizing enzymes, transporters, cellular targets and signaling pathways. Th e identifi cation of genetic variations that predict for drug response is an important step towards the trans...

a system approach to the pharmacogenetics of migraine

A New Approach to PCSK9 Therapeutics

PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition is an effective therapy to reduce low-density lipoprotein cholesterol and cardiovascular events. A recent study shows that 1 or 2 doses of inclisiran, a long-acting synthetic small-interfering RNA that selectively targets hepatic PCSK9, causes a sustained reduction of plasma low-density lipoprotein cholesterol for ≤6 months. Pendi...